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Erik K. St. Louis, Barry E. Gidal, Thomas R. Henry, Yevgenya Kaydanova, Allan Krumholz, Paul H. McCabe, Georgia D. Montouris, William E. Rosenfeld, Brien J. Smith, John M. Stern, Elizabeth J. Waterhouse, Richard M. Schulz, William R. Garnett, Thomas Bramley

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Blue Radiance Scarpa Scarpa Grey Womens Womens Abstract

To develop expert consensus for conversion between antiepileptic drug (AED) monotherapies, an 11-member panel used the Delphi Technique over three rounds to: (1) identify relevant issues, (2) vote on the issues, and (3) develop consensus. The panel agreed on the basic principle to taper the existing AED only after a presumably efficacious dose of the planned AED was reached. Application is modified by adverse effects possibly attributable to the existing drug, in which case earlier or more rapid tapering of the existing drug should be considered. Patients with uncontrolled seizures, as well as seizure-free patients for whom driving privileges are a consideration, may benefit from slower tapering by smaller dosage decrements of the existing AED. For 10 of the 12 AEDs considered, the panel made titration recommendations concerning initial and target doses for the planned AED, supplementing limited data in the prescribing information. This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy.

Language English (US)
Pages 222-234
Number of pages Radiance Scarpa Scarpa Womens Womens Blue Grey 13
Journal Epilepsy and Behavior
Volume 11
Issue number 2
Scarpa Womens Radiance Womens Grey Blue Scarpa DOIs
Radiance Blue Womens Scarpa Grey Womens Scarpa State Published - Sep 2007
Blue Scarpa Scarpa Womens Grey Radiance Womens Externally published Yes

Keywords

  • Antiepileptic drugs
  • Conversion
  • Delphi Technique
  • Epilepsy
  • Expert opinion
  • Monotherapy
  • Polytherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Grey Scarpa Scarpa Womens Radiance Womens Blue St. Louis, E. K.Sandal Commute Women's Metallic Heeled Seychelles Tribal v1nqwwtx5z, Gidal, B. E., Henry, T. R., Kaydanova, Y., Krumholz, A., McCabe, P. H., ... Bramley, T. (2007). Conversions between monotherapies in epilepsy: Expert consensus. Epilepsy and Behavior, 11(2), 222-234. DOI: 10.1016/j.yebeh.2007.04.007
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